8 May Understanding How The Bacteria In Our Gut Affects Diabetes May 8, 2017 By The Fraternal Order of Eagles Diabetes Research Center 2 DRC Director's Report, May 2017 Diabetes significantly increases the risk for heart attacks and stroke. However treating blood sugar levels and even high cholesterol in the blood might not completely prevent these complications of diabetes. For this reason many researchers are looking for new connections between diabetes and vascular disease. FOEDRC researchers Dr. Ajit Vikram and Kaikobad Irani recently published an important discovery in the Journal Nature Communications that provides new understanding of why blood vessel inflammation and damage occurs in subjects at high risk for cardiovascular disease. Their work discovered a previously undiscovered interaction between bacteria in the gut, which had previously been implicated in diabetes risk, and cardiovascular complications. The trillions of bacteria that colonize the gut play multiple roles in health and disease. Certain forms of gut bacteria promote diabetes, lead to weight gain, and also play an important part in heart disease. This work illustrates a new mode of communication between bacteria in the gut and blood vessels, and how this communication leads to malfunction of blood vessels that can eventually precipitate plaque build-up and lead to heart disease. The gut bacteria signal through the blood stream to change expression of a class of small RNAs, termed microRNAs in the wall of the blood vessel. These microRNAs then target genes that maintain vascular health. Thus, this remote yet intricate communication between the gut and blood vessels impairs normal and healthy functioning of these vessels. It has been said that the way to man’s heart is through is stomach. These remarkable findings suggest that might be true! Importantly they lay important groundwork for developing new approaches and targets for reducing cardiovascular complications in high-risk subjects with diabetes. Related DRC Researchers Publish Major Breakthrough In Understanding How Diabetes Induces Eye Damage In the retina, diabetes damages nerves before it damages blood vessels. Diabetes is a major risk factor for severe vision loss and blindness. A condition known as retinal diabetic neuropathy causes visual impairment through the degeneration of small nerves (neurons) in light-sensitive tissue called the retina, which lines the back of the eye. How Diabetes Harms The Heart Study in mice involving FOEDRC researchers, reveals heart-damaging pathway triggered by insulin, identifies possible drug targets to prevent or treat heart failure. Diabetes is hard on the heart. Cardiovascular disease is the leading cause of death in people with diabetes, and risk for heart failure—where the heart can’t pump enough blood—is two to three times higher in men and up to five times higher in women with diabetes compared to people without diabetes. Progress In Preventing Eye Disease In Diabetes A research team lead by Mark A. Greiner, M.D., Assistant Professor, Cornea and External Diseases in the Department of Ophthalmology and Visual Sciences and member of the FOEDRC, at the University of Iowa is doing interesting work in understanding how diabetes affects the Cornea. Casey Receives Grant Funding from American Diabetes Association Congratulations to Darren Casey, PhD, assistant professor of physical therapy and rehabilitation science, for recently receiving the American Diabetes Association Innovative Clinical or Translational Science Award. For his proposal entitled - Nitrate supplementation and exercise tolerance in patients with Type 2 Diabetes. Dr. Casey received this award after a National Competition that selected a fraction of the most meritorious proposals. A Vitamin For Diabetes And Its Complications? Prediabetes, type 2 diabetes (T2D), and diabetes that is complicated by nerve damage (neuropathy) are increasingly common conditions worldwide. These conditions are the result of progressive problems in metabolism. Prediabetes and T2D are characterized by increasing levels of blood sugar and circulating fats (lipids) in conjunction with insulin resistance. Many prediabetics and half of T2D patients develop progressive damage to their nerves that can be painful or lead to a loss of sensation. Diabetic neuropathy can lead to loss of limbs and is severely debilitating. We know that weight management and keeping active are among the most important components for preventing these conditions and arresting their progression. However, scientists are always on the lookout for healthy ingredients that can help people control their weight, improve their blood glucose control, and help their nerves stay healthy. Recent research at the University of Iowa, supported by the Fraternal Order of Eagles Diabetes Research Center (FOEDRC), suggests that an over-the-counter vitamin supplement called nicotinamide riboside (NR) may do just that. An M-Health Intervention To Increase Activity Among Patients At Risk For Type 2 Diabetes In 2013, Dr. Philip Polgreen was the recipient of a FOEDRC Pilot Grant for his research entitled, “To evaluate a novel tool using text messages as a mechanism to promote sustained weight loss in patients with obesity and insulin resistance.” This cutting edge science was recently recognized and awarded additional funding by the National Institutes of Health (NIH). Showing 2 Comments tom What gut bacteria affects the wellness, and what kind of food will do this? last month Andrew Montgomery The article "How the bacteria in our gut effects diabetes" has a simple grammar error in title. It should read "How the bacteria in our gut affects diabetes"Andrew MontgomeryPWP #265 last month Comments are closed.