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The latest news from the Fraternal Order of Eagles

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Dr. Abel Named President-Elect Of The Endocrine Society

DRC Director's Report - December 2017

It is with great pleasure that we share with you that E. Dale Abel, MD, PhD, was recently elected as the president-elect of the Endocrine Society. His term as president-elect will commence March 20, 2018, and his presidential term will begin on March 20, 2019, for one year.  Dr. Abel credits this high accomplishment in part to the contributions of the FOE whose extraordinary commitment to diabetes research has strengthened his work.

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New Ways To Predict The Risk Of Gestational Diabetes

DRC Director's Report - November 2017

We are pleased to announce that Dr. Wei Bao, Assistant Professor in the Department of Epidemiology, College of Public Health, University of Iowa, and a member of the Fraternal Order of Eagles Diabetes Research Center (FOEDRC) was recently awarded a $419,000 grant from the National Institutes of Health to fund a project entitled: Pregnancy-associated microRNAs in plasma as predictors of gestational diabetes.  Some of the preliminary work that contributed to this award were provided by pilot funding from the FOEDRC.

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New Muscle Wasting Research Holds Promise at UI

DRC Director's Report, October 2017

A hearty “Congratulations!” is in order for Dr. Christopher Adams, Professor of Endocrinology and Metabolism, and member of the FOE DRC who is the recipient of a five-year, $2.4M grant from the National Institutes of Health to study skeletal muscle atrophy. Dr. Adams holds an FOEDRC endowed chair, and this recent success underscores the important impact of the investment of the FOEDRC towards the ongoing success of his research program.  In preliminary studies, performed in mouse models, Dr. Adams and members of his lab identified the first example of a protein that is required for the loss of skeletal muscle mass, quality, strength, and endurance exercise capacity during aging: the transcription factor ATF4.

 

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Stressing Muscle Metabolism Prevents Obesity and Type 2 Diabetes

Exciting new research was recently published in the EMBO Journal by the laboratory of FOEDRC Director, Dale Abel.   The study suggests that gently stressing muscle metabolism could help prevent obesity and type 2 diabetes.  The study was carried out on mice where the team found triggering a type of metabolic stress increased levels of a hormone called fibroblast growth factor-21 (FGF21).  The findings showed the animals were completely protected from obesity and diabetes. Interestingly, in the mice which had already started to develop the condition, the hormone reversed the diabetes and helped them return to a normal weight with normal blood sugar levels.

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Chemicals in Plastic Bottles and the Risk of Obesity and Diabetes

DRC Director's Report, August 2017

As you all know, there are many factors that may contribute to the growing risk of obesity and diabetes worldwide. Many understand that an unhealthy diet, gaining too much weight or not exercising enough will certainly contribute to increasing your risk of diabetes.  However, there is also a growing realization that certain environmental exposures and chemicals to which we might be exposed could also increase this risk.

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FOEDRC Continues To Lead In Studies Increasing Our Understanding of FGF21

DRC Director's Report, July 2017

As diabetes researchers work to identify potential new treatments for diabetes, colleagues at the FOEDRC continue to advance our understanding of how newly discovered hormones might work in ways that may lead to new ways to treat and prevent obesity and diabetes. One such hormone is fibroblast growth factor 21 (FGF21). Dr. Matthew Potthoff recently showed in mice that this hormone critically regulates the “sweet tooth” in mice. In a recent follow up study with collaborators from Denmark and published in the Journal Cell Metabolism,  it is now confirmed that FGF21 also regulates sweet preference in humans.  Now, Dr. Potthoff’s team has solved another piece of the puzzle by showing how and where FGF21 might act to regulate the body’s metabolism.

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DRC Receives $2.02 Million Training Grant From National Institutes of Health

I am pleased to share with you that Dr. E. Dale Abel, Director of the Fraternal Order of Eagles Diabetes Research Center (FOEDRC) and Chair of the Department of Internal Medicine, and Dr. Andrew (Andy) Norris, FOEDRC’s Associate Director, have just been awarded a five-year, $2.02M training grant from the National Institutes of Diabetes, Digestive and Kidney Diseases of the National Institutes of Health. The T32 grant will fund the Diabetes Research Training Program at the University of Iowa and will support up to six post-doctoral trainees or subspecialty fellows per year. The grant will support existing trainees or support the recruitment of outstanding new trainees to the University of Iowa.

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Understanding How The Bacteria In Our Gut Affects Diabetes

DRC Director's Report, May 2017

Diabetes significantly increases the risk for heart attacks and stroke. However treating blood sugar levels and even high cholesterol in the blood might not completely prevent these complications of diabetes. For this reason many researchers are looking for new connections between diabetes and vascular disease. FOEDRC researchers Dr. Ajit Vikram and Kaikobad Irani recently published an important discovery in the Journal Nature Communications that provides new understanding of why blood vessel inflammation and damage occurs in subjects at high risk for cardiovascular disease.

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ADA To Honor Career Achievements of Daryl Granner, MD

DRC Director's Report, April 2017

Dr. Daryl Granner is the founding director of the Fraternal Order of Eagles Diabetes Center (FOEDRC). He is a stalwart in diabetes research and I am deeply grateful for the groundwork which he laid in putting in place the structure and framework around which the FOEDRC has been built and for his ongoing commitment to our success. Thus, I was particularly pleased to learn that Dr. Granner will be recipient of one of the most prestigious awards granted for a life-long commitment to diabetes research from the American Diabetes Association.

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How Diabetes Harms The Heart

Study in mice involving FOEDRC researchers, reveals heart-damaging pathway triggered by insulin, identifies possible drug targets to prevent or treat heart failure.

Diabetes is hard on the heart.

Cardiovascular disease is the leading cause of death in people with diabetes, and risk for heart failure—where the heart can’t pump enough blood—is two to three times higher in men and up to five times higher in women with diabetes compared to people without diabetes.