Latest News

DRC Director's Report - February 2021

The exact mechanisms underlying the metabolic effects of gastric bypass or bariatric surgery remain unclear. At the University of Iowa Carver College of Medicine, Mohamad Mokadem, MD, Assistant Professor of Internal Medicine and member of FOEDRC, and his research team have developed an animal model of bariatric surgery, which they are using to understand the underlying mechanisms by which this treatment not only prevents obesity but also reverses diabetes.

DRC Director's Report - January 2021

A recent study by a team of UI researchers led by E. Dale Abel, MD, PhD, Director, FOEDRC discovered eating a ketogenic diet rescued mice from heart failure. 

The study, published in the November issue of the journal Nature Metabolism, was one of three companion papers from independent research teams that all point to the damaging effects of excess sugar (glucose) and its breakdown products on the heart. The UI study also revealed the potential to mitigate that damage by supplying the heart with alternate fuel sources in the form of high-fat diets. 

Given its need for a constant, reliable supply of energy, the heart is very flexible about the type of molecules it can burn for fuel. Most of the heart’s energy comes from metabolizing fatty acids, but heart cells can also burn glucose and lactate, and also ketones. 

DRC Director's Report - December 2020

Dr. Vitor Lira Associate Professor of Health and Human Physiology and member of the FOEDRC was recently awarded a new grant from the National Institutes of Health in the amount of $563,723. The grant entitled: “Molecular regulation of protein turnover in skeletal muscle” will study an important condition that afflicts many individuals as they age, particularly those with diabetes. 

Aging-related skeletal muscle atrophy and weakness, also referred to as sarcopenia, affects millions of people contributing to the development of several chronic conditions associated with poor health outcomes, such as diabetes, cardiovascular diseases and neurodegenerative diseases. Although sarcopenia remains poorly understood and lacks effective therapy, aged muscles manifest a problem of poor protein turnover or recycling which is called proteotoxicity. 

DRC Director's Report - November 2020

FOE Diabetes Research Center scientists from the University of Iowa have discovered a safe new way to manage blood sugar non-invasively. Exposing diabetic mice to a combination of static electric and magnetic fields for a few hours per day normalizes two major hallmarks of type 2 diabetes, namely reducing blood glucose levels and preventing insulin resistance. These new findings were published Oct. 6 in Cell Metabolism.

DRC Director's Report - October 2020

Please join us in welcoming Bhagirath Chaurasia, MS, PhD, to the University of Iowa and to the Fraternal Order of Eagles Diabetes Research Center. Dr. Chaurasia also joins the Division of Endocrinology from his previous position as Assistant Professor of Nutrition and Integrative Physiology at the University of Utah. He received his PhD from the University of Cologne in Germany before working as a Postdoctoral Research Fellow at Duke-NUS Medical School in Singapore.

DRC Director's Report - September 2020

Renata Pereira, PhD, Research Assistant Professor of Internal Medicine, Endocrinology and Metabolism, and member of the FOEDRC, is the recipient of a new NIH R01 grant for $1.9M to support her work entitled The role of the integrated stress response in brown adipose tissue-mediated metabolic adaptations. 

“Obesity and related conditions, such as diabetes and heart disease, are some of the greatest health problems affecting today’s society. In an effort to better understand ways in which the body can increase its metabolism to burn fat and prevent the effects of those diseases, Dr. Pereira has focused her studies on special fat cells called brown (or beige) fat cells.

DRC Director's Report - August 2020

The prevalence of obesity continues to increase worldwide due to changes in dietary composition including the addition of sweetners to many food products and evolving patterns of eating behaviors. In particular, excessive consumption of sugars has been linked to metabolic diseases such as diabetes, insulin resistance and type 2 diabetes. 

Fibroblast growth factor 21 (FGF21) is a liver-derived hormone that signals to the brain to reduce sugar intake, but the mechanism for this effect was unknown. This new study by Ph.D. student Sharon Jensen-Cody and other colleagues in the laboratory of Matt Potthoff, Associate Professor in the Fraternal Order of Eagles Diabetes Center and Department of Pharmacology and Neuroscience discovered that FGF21 signals to specific nerve cells called glutamatergic neurons in the brain to lower sugar intake and sweet-taste preference.

DRC Director's Report - July 2020

The greatest risks to long-term health in people with diabetes arise from diabetic complications, particularly cardiovascular disease. However, the mechanisms by which the metabolic changes associated with type 2 diabetes like insulin resistance increases the risk of heart failure are less understood. In a recent publication in JCI Insight, E. Dale Abel, MD, PhD, and other members of the Fraternal Order of Eagles Diabetes Research Center in collaboration with other institutions, have uncovered an important molecular link between diabetes and heart failure.

DRC Director's Report - June 2020

FOEDRC members Al Klingelhutz, PhD, Professor of Microbiology & Immunology and Radiation Oncology and James Ankrum, PhD, Assistant Professor of Biomedical Engineering, have received funding as part of the Iowa Superfund Research Program (ISRP). As co-directors of 1 of the 5 projects, “Role of Airborne PCBs in Adipogenesis, Adipose Function, and Metabolic Syndrome”, they will focus on how the environmentally prevalent toxin PCB ) (polychlorinated biphenyls) accumulation in fat affects the development of obesity, fatty liver disease, and type II diabetes. The ISRP, headed by Keri Hornbuckle, PhD, Professor of Civil and Environmental Engineering, will receive a total of $11.4 million over a 5-year period to continue its research on polychlorinated biphenyls, or PCBs, and the impact they have on human health.

DRC Director's Report - May 2020

Diabetes is a disease of uncontrollable high blood glucose. Insulin, the hormone that reduces blood glucose, is secreted from beta cells embedded in the pancreas in structures called islets. Although overnutrition has been blamed for the inability of beta cells to secrete enough insulin in type 2 diabetes, it has remained unclear how overnutrition causes beta cells to fail. This is a critical question to solve in order to develop effective therapy to protect beta cells in conditions of overnutrition and to cure type 2 diabetes.