11 August DRC Director's Report - August 2022 August 11, 2022 By The Fraternal Order of Eagles Diabetes Research Center DRC, Iowa, Diabetes, Diabetes Research Center 0 This June, the American Diabetes Association (ADA) hosted its 82nd Scientific Sessions in New Orleans, LA. Each year, thousands of attendees join together from across the world to hear the latest cutting-edge research. Sharing the latest scientific findings, the annual meeting is the largest and most important gathering focused on diabetes research. The ADA is the nation’s leading voluntary health organization fighting to bend the curve on the diabetes epidemic and help people living with diabetes thrive. For 82 years, the ADA has driven research to treat, manage and prevent diabetes while also working relentlessly for a cure. Diabetes is the most common underlying chronic condition in the United States. 133 million Americans currently live with diabetes or prediabetes and, in the last 20 years, the number of Americans with diagnosed diabetes has more than doubled. The ADA is focused on timely, critical advancements in diabetes research and care. This year, the University of Iowa was featured in a short film shown at the ADA meeting. The Fraternal Order of Eagles Diabetes Research Center (FOEDRC) is one of the leaders in diabetes research, focused on understanding the development of diabetes, how to better manage diabetes, and how to improve the treatment of diabetes. The FOEDRC was founded in 2008 when the Fraternal Order of Eagles pledged $25 million to establish a world class diabetes research center at the University of Iowa. With this gift, the FOEDRC has grown to include over 100 faculty members involved in diabetes research and brings in over $30 million of funding from the NIH annually. The short film presented at the ADA scientific meeting highlights FOEDRC co-directors, Andy Norris, MD, PhD and Kamal Rahmouni, PhD, along with colleagues, Ayotunde Dokun, MD, PhD, Yumi Imai, MD, and Katie Larson-Ode, MD. Link: https://www.youtube.com/watch?v=mMkzg-BNKBc Related Articles DRC Director's Report - July 2022 Recently, the University of Iowa Fraternal Order of Eagles Diabetes Research Center (FOEDRC) held our annual Diabetes Research Day in collaboration with the University of Minnesota Institute for Diabetes, Obesity and Metabolism. This year, Diabetes Research Day was a hybrid event comprised of speakers from both institutions and split into two different events. Our first keynote speaker was Bryan Bergman, PhD. Professor in the Division of Endocrinology, Metabolism and Diabetes at the University of Colorado Anschutz Medical Campus who gave a talk entitled Intermuscular Adipose Tissue: A Novel Adipose Depot Impacting Muscle Strength, Size, and Insulin Sensitivity in Humans. DRC Director's Report - August 2021 Postdoctoral research scholar, Calvin Carter, PhD, member of the FOEDRC and recipient of the prestigious FOE Bridge to the Cure award, in collaboration with other FOEDRC researchers, has discovered a safe new way to manage blood sugar non-invasively. Exposing diabetic mice to a combination of static electric and magnetic fields for a few hours per day normalized blood glucose levels and reversed insulin resistance. “The more we look, the more the transfer of electrons seems to underlie diabetes,” Carter said in a Q&A with the American Diabetes Association (ADA). That search was borne out last fall, when Carter and MD/PhD student Sunny Huang, PhD, published ground-breaking findings in Cell Metabolism, showing that static electric and magnetic fields (EMFs) can be used to normalize blood glucose in diabetic mice. Reactions in the press were excited and swift to the researchers’ evidence that blood sugar and insulin sensitivity could be controlled non-invasively. DRC Director's Report - September 2022 Over the past decade, evidence has emerged indicating that high blood sugars in type 1 diabetes cause adverse brain changes in children. The adverse changes include abnormal brain structural alterations and reduced functioning on some cognitive tests. Over the past few years, hybrid closed-loop insulin pumps have become commercially available. These devices combine a continuous glucose monitor (CGM) with an insulin pump that is controlled by an algorithm that uses the CGM data to inform insulin delivery. DRC Director's Report - August 2020 The prevalence of obesity continues to increase worldwide due to changes in dietary composition including the addition of sweetners to many food products and evolving patterns of eating behaviors. In particular, excessive consumption of sugars has been linked to metabolic diseases such as diabetes, insulin resistance and type 2 diabetes. Fibroblast growth factor 21 (FGF21) is a liver-derived hormone that signals to the brain to reduce sugar intake, but the mechanism for this effect was unknown. This new study by Ph.D. student Sharon Jensen-Cody and other colleagues in the laboratory of Matt Potthoff, Associate Professor in the Fraternal Order of Eagles Diabetes Center and Department of Pharmacology and Neuroscience discovered that FGF21 signals to specific nerve cells called glutamatergic neurons in the brain to lower sugar intake and sweet-taste preference. DRC Director's Report - May 2022 Obesity causes a buildup of fat metabolites, including a toxic lipid molecule ceramide. Buildup of ceramide worsens health because it contributes to the development of diabetes and other diseases. Previous work has shown that targeting ceramide is an effective strategy to treat obesity, diabetes and associated cardiovascular disease. This can be achieved using a molecule called myriocin which is a very potent inhibitor of ceramide generation. Myriocin-mediated reduction of ceramide levels was found to be an effective way to treat obesity and associated diseases in rodents. Myriocin, which is not approved for use in humans, is abundant in a number of fungal species including the one called Cordyceps which is routinely consumed as part of traditional Chinese medicine used for the treatment of numerous diseases including diabetes. DRC Director's Report - June 2022 On May 24, 2022, Fraternal Order of Eagles members joined the University of Iowa President, College of Medicine Executive Dean, faculty, staff and students for an investiture ceremony honoring three Carver of College of Medicine faculty. Showing 0 Comment Comments are closed.