7 June DRC Director's Report - June 2022 June 7, 2022 By The Fraternal Order of Eagles Diabetes Research Center 0 On May 24, 2022, Fraternal Order of Eagles members joined the University of Iowa President, College of Medicine Executive Dean, faculty, staff and students for an investiture ceremony honoring three Carver of College of Medicine faculty. The investiture celebrated faculty appointments to endowed chairs established by the Fraternal Order of Eagles. Dr. Sue Bodine was conferred the Fraternal Order of Eagles Diabetes Research Center Chair. Dr. Bodine is a professor in the Department of Internal Medicine. Her research centers on the study of the neuromuscular system and its response and adaptation to stressors, including obesity, diabetes, and aging. Her laboratory is working to identify the mechanisms responsible for muscle atrophy and deter-mine strategies for preventing atrophy and accelerating muscle recovery. The Verna Funke Fraternal Order of Eagles Diabetes Research Center Chair was bestowed on Dr. Ayotunde Dokun who is an associate professor and director of the Division of Endocrinology and Metabolism in the Department of Internal Medicine. He performs research on Type 1 and Type 2 diabetes and diabetes-associated peripheral arterial disease, with the goal of preventing diabetes-related limb amputations. Finally, the E. Dale Abel Fraternal Order of Eagles Diabetes Research Center Chair was given to Dr. Kamal Rahmouni who is professor in the Department of Neuroscience and Pharmacology and interim co-director of the Fraternal Order of Eagles Diabetes Research Center. The work in Dr. Rahmouni’s laboratory is focused on the neurobiology of metabolism, energy homeostasis, and cardiovascular function as relates to obesity, diabetes, and hypertension. The goal of his research is to identify the neuroanatomical and molecular pathways involved in the regulation of metabolic, autonomic, and cardiovascular functions. A reception followed the ceremony outside of the Fraternal Order of Eagles Diabetes Research Center, located in the Pappajohn Biomedical Discovery Building. Related Articles DRC Director's Report - June 2021 Pancreatic beta cells are only cells that can make insulin in humans. In type 2 diabetes, pancreatic beta cells are damaged and cannot make sufficient insulin to keep blood glucose levels normal. As overnutrition and obesity is a well-known risk factor for type 2 diabetes, it is important to find a way to protect beta cells from over nutrition. In a recently published study in the scientific journal JCI Insight, led by Dr. Yumi Imai, Associate Professor of Internal Medicine and member of the FOEDRC, her laboratory has discovered that a protein known as Perilipin 2 plays an important role in protecting beta cells under nutritional challenge. DRC Director's Report - May 2022 Obesity causes a buildup of fat metabolites, including a toxic lipid molecule ceramide. Buildup of ceramide worsens health because it contributes to the development of diabetes and other diseases. Previous work has shown that targeting ceramide is an effective strategy to treat obesity, diabetes and associated cardiovascular disease. This can be achieved using a molecule called myriocin which is a very potent inhibitor of ceramide generation. Myriocin-mediated reduction of ceramide levels was found to be an effective way to treat obesity and associated diseases in rodents. Myriocin, which is not approved for use in humans, is abundant in a number of fungal species including the one called Cordyceps which is routinely consumed as part of traditional Chinese medicine used for the treatment of numerous diseases including diabetes. DRC Director's Report - April 2022 A research team that includes several FOEDRC faculty recently published an article describing a new approach to help treat type 2 diabetes. The research team included FOEDRC faculty members Robert Kerns PhD, Andrew Norris MD PhD, Eric Taylor PhD, Yumi Imai MD, and Jessica Smith MD. Also recognized in the publication was Wojciech Grzesik, PhD, who is a research scientist in the FOEDRC metabolic phenotyping core. The work was published in the prestigious journal "Nature Communications" and can be found at this link : https://pubmed.ncbi.nlm.nih.gov/35145074/ DRC Director's Report - June 2020 FOEDRC members Al Klingelhutz, PhD, Professor of Microbiology & Immunology and Radiation Oncology and James Ankrum, PhD, Assistant Professor of Biomedical Engineering, have received funding as part of the Iowa Superfund Research Program (ISRP). As co-directors of 1 of the 5 projects, “Role of Airborne PCBs in Adipogenesis, Adipose Function, and Metabolic Syndrome”, they will focus on how the environmentally prevalent toxin PCB ) (polychlorinated biphenyls) accumulation in fat affects the development of obesity, fatty liver disease, and type II diabetes. The ISRP, headed by Keri Hornbuckle, PhD, Professor of Civil and Environmental Engineering, will receive a total of $11.4 million over a 5-year period to continue its research on polychlorinated biphenyls, or PCBs, and the impact they have on human health. DRC Director's Report - February 2022 On January 3rd, 2022, we celebrated the career of FOEDRC faculty member Dr. Eva Tsalikian on the occasion of her well-earned retirement. For over 4 decades, Dr. Tsalikian has been tireless in her pursuit of better treatments for children with diabetes. Her research work earned her the 2011 Mary Tyler Moore & S. Robert Levine Excellence in Clinical Diabetes Research award and she was the 2013 Honoree at the Eastern Iowa Juvenile Diabetes Research Foundation gala. DRC Director's Report - January 2022 It is with mixed emotions, but with a sense of great pride in our accomplishments that I write this my final Director’s report. When I came to the University of Iowa nearly 9-years ago, I was given a challenge to leverage the generous gift of the Fraternal Order of Eagles, to develop a world class diabetes research center. I reflected back on where things were at the University of Iowa in 2008, when the FOE began your campaign for the Diabetes Research Center and where they are now. In 2008, there were 5 faculty members identified as doing diabetes research with a total team of 20. We had 10 grants received and approximately $1M in funding from the National Institute of Health. Showing 0 Comment Comments are closed.