16 May DRC Director's Report - May 2022 May 16, 2022 By The Fraternal Order of Eagles Diabetes Research Center DRC, Diabetes, Diabetes Research Center, Iowa, Charity Foundation 0 Obesity causes a buildup of fat metabolites, including a toxic lipid molecule ceramide. Buildup of ceramide worsens health because it contributes to the development of diabetes and other diseases. Previous work has shown that targeting ceramide is an effective strategy to treat obesity, diabetes and associated cardiovascular disease. This can be achieved using a molecule called myriocin which is a very potent inhibitor of ceramide generation. Myriocin-mediated reduction of ceramide levels was found to be an effective way to treat obesity and associated diseases in rodents. Myriocin, which is not approved for use in humans, is abundant in a number of fungal species including the one called Cordyceps which is routinely consumed as part of traditional Chinese medicine used for the treatment of numerous diseases including diabetes. In a recently published study, FOEDRC member, Dr. Chaurasia, and his team screened extracts of Cordyceps currently being consumed by humans to identify those containing myriocin and tested their efficacy in improving body weight and glucose in obese animals. Interestingly, they identified several commercially available Cordyceps that contain myriocin. When they treated obese mice with a human equivalent dose of Cordyceps extract containing myriocin they found it was effective in reducing ceramide accumulation. This treatment was also successful in preventing obesity and improving blood glucose and liver disease. This study provides proof-of-principle that inhibiting the buildup of ceramide using myriocin containing Cordyceps extract improves not only obesity, but also diabetes and liver disease. Collectively, this work identifies commercially available Cordyceps as a readily available supplement to treat obesity and associated diseases. Related Articles DRC Director's Report - June 2022 On May 24, 2022, Fraternal Order of Eagles members joined the University of Iowa President, College of Medicine Executive Dean, faculty, staff and students for an investiture ceremony honoring three Carver of College of Medicine faculty. DRC Director's Report - April 2022 A research team that includes several FOEDRC faculty recently published an article describing a new approach to help treat type 2 diabetes. The research team included FOEDRC faculty members Robert Kerns PhD, Andrew Norris MD PhD, Eric Taylor PhD, Yumi Imai MD, and Jessica Smith MD. Also recognized in the publication was Wojciech Grzesik, PhD, who is a research scientist in the FOEDRC metabolic phenotyping core. The work was published in the prestigious journal "Nature Communications" and can be found at this link : https://pubmed.ncbi.nlm.nih.gov/35145074/ DRC Director's Report - February 2022 On January 3rd, 2022, we celebrated the career of FOEDRC faculty member Dr. Eva Tsalikian on the occasion of her well-earned retirement. For over 4 decades, Dr. Tsalikian has been tireless in her pursuit of better treatments for children with diabetes. Her research work earned her the 2011 Mary Tyler Moore & S. Robert Levine Excellence in Clinical Diabetes Research award and she was the 2013 Honoree at the Eastern Iowa Juvenile Diabetes Research Foundation gala. DRC Director's Report - January 2022 It is with mixed emotions, but with a sense of great pride in our accomplishments that I write this my final Director’s report. When I came to the University of Iowa nearly 9-years ago, I was given a challenge to leverage the generous gift of the Fraternal Order of Eagles, to develop a world class diabetes research center. I reflected back on where things were at the University of Iowa in 2008, when the FOE began your campaign for the Diabetes Research Center and where they are now. In 2008, there were 5 faculty members identified as doing diabetes research with a total team of 20. We had 10 grants received and approximately $1M in funding from the National Institute of Health. DRC Director's Report - March 2022 Recently the International Journal of Science featured important research by a member of the FOEDRC, Ayotunde Dokun, MD, PhD, Director of the Division of Endocrinology and Metabolism and his team. Peripheral arterial disease is the narrowing or blockage of the vessels that supply blood to lower extremities. This disease affects millions of individuals with diabetes and is considered a major complication of diabetes which often lead to limb amputation. DRC Director's Report - December 2018 As we come to the end of another successful year for the FOEDRC, I want to thank the FOE and my colleagues within the Diabetes Research Center for continuing to push the research boundaries to improve the lives of many who suffer from diabetes. On a personal note, I received a number of honors for my work this year including being asked to deliver the Presidential Lecture of the University of Iowa, receiving Fraternal Order of Eagles Humanitarian Award and the 2018 History Makers Award - the African American Museum of Iowa (AAMI). My receipt of this recognition is really a recognition of what you do and I consider myself very fortunate to lead such an outstanding organization. To close out the year I thought you might be interested in reading about some ways that our researchers are turning “fun and games” into a benefit for our patients with diabetes. Showing 0 Comment Comments are closed.