30 May DRC Director's Update - June 2019 May 30, 2019 By The Fraternal Order of Eagles Diabetes Research Center 0 In healthy adults, blood pressure (BP) decreases during sleep at night to lower levels than during the daytime. This phenomenon is referred to as nocturnal BP “dipping” and normally dips 10-20% compared with daytime. Blunted nocturnal BP dipping has been independently associated with increased cardiovascular disease (CVD) risk. The prevalence of blunted nocturnal BP dipping is higher in persons with obesity and diabetes, which are traditional risk factors for CVD. Aortic stiffness and inflammation are emerging as novel CVD risk factors, but whether there is an association between these factors and nocturnal BP dipping has not been well-described. The team of FOEDRC member Gary Pierce, that was led by Dr. Abbi Lane-Cordova, hypothesized that evidence of poor glucose control, inflammation and aortic stiffness would be inversely associated with the relative magnitude of nocturnal systolic BP dipping among middle-aged/older adults with obesity at elevated CVD risk. Twenty-four hour ambulatory BP monitoring, aortic stiffness (carotid-femoral pulse wave velocity, CF-PWV), glucose control characterized by hemoglobin A1c (HbA1c) and inflammation (C-reactive protein, CRP) were measured in 86 middle-aged/older adults with obesity and at least one other CVD risk factor. The age of study participants ranged from 40-74 years and included 34 men and 52 women and 50 had prediabetes. The major predictor of impaired nocturnal blood pressure dipping In the entire cohort of 86 adults was the circulating concentrations of CRP. In individuals with prediabetes, HbA1c (a measure of glucose control) and CRP were independently associated with systolic BP dipping percent in obese adults with prediabetes. There were no significant associations in obese adults without prediabetes, even though nocturnal systolic BP dipping percent, CF-PWV, and CRP were similar between participants with and without prediabetes. These data reveal abnormal control of systolic BP dipping in adults with obesity and prediabetes. They indicate that even before diabetes is diagnosed in men and women who are overweight and at increased risk of developing diabetes, there is evidence of whole body inflammation that may contribute to blunted BP dipping. Thus cardiovascular health is already significantly impaired in high-risk individuals before diabetes is diagnosed. These findings were published in the Journal Hypertension Research. Related Articles DRC Director's Report - March 2019 Brian T. O’Neill, MD, PhD, assistant professor in the Division of Endocrinology in the Department of Internal Medicine and member of the FOEDRC recently published in the journal Diabetes the discovery that FoxO proteins, which are transcription factors that regulate DNA, are the critical regulators of diabetes-related muscle atrophy. DRC Director's Report - April 2019 In a recent study done by Wei Bao, MD, PhD, assistant professor in the Department of Epidemiology and member of the FOEDRC, his research team found that frequent consumption of fried foods, especially fried chicken and fried fish/shellfish, was associated with a higher risk of death from all causes and cardiovascular disease in women in the United States. Women with at least one serving per week of fried chicken had a 13% higher risk of death from all causes, and a 12% higher risk of death from cardiovascular disease, when compared with women with no consumption of fried chicken. DRC Director's Report - January 2019 The new year is always a time to look back and reflect on the many achievements of the prior year. I have been pleased that the Fraternal Order of Eagles has committed continued support to a program that will be overseen by the FOEDRC that seeks to develop new treatments for diabetes and its complications and to bring them ultimately to market. The Bridge to the cure program represents an innovative collaboration and we are excited by what this new year will bring. For this reason, I have chosen to write about one example from a FOEDRC member that recently demonstrated the ability of the compound nicotinamide riboside to restore nerve damage from chemotherapy. We believe that this same mechanism could lead to improved nerve function in people with diabetes. I hope that you will enjoy reading about this exciting advance below. DRC Director's Report - February 2019 The Department of Defense office of the Congressionally Directed Medical Research Programs has awarded DRC member, Ethan Anderson, Associate Professor College of Pharmacy, funding as part of its Peer Reviewed Medical Research Program (PRMRP) Discovery Award competition. The project is: Exploiting the Paracrine-Like Effect of Prohibitin-1 to Treat Septic Cardiomyopathy. The grant will provide $310,000 in total support over a 2-year period. DRC Director's Report - May 2019 E. Dale Abel, MD, PhD, was elected as the president-elect of the Endocrine Society in October of 2017. At the annual scientific meeting of the Endocrine Society in New Orleans, Dr. Abel was sworn in as the Endocrine Society’s newest president. His one year presidential term began on March 20, 2019. October 2018 Diabetes Research Center Update Ryan Boudreau, PhD, Assistant Professor in the Division of Cardiology in the Department of Internal Medicine and a member of the FOEDRC recently discovered a new protein-coding gene in the human genome that regulates mitochondria. These studies were simultaneously published in the Journal Cell Reports at the same time as a study from a laboratory at the University of Texas Southwestern Medical Center that made a similar discovery. Showing 0 Comment Comments are closed.